Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.33 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.33 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.33 |
| ▸ | ITGAV | P06756 | 1/20 | 0.33 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.33 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.33 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.33 |
| ▸ | ITGAL | P20701 | 1/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 3/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.30 |
| ▸ | LCK | P06239 | 1/20 | 0.30 |
| ▸ | FYN | P06241 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetamide SCHEMBL5182199 | 0.91 | BLM (0.35) | CRBNMTNR1APDE4APDE4BPDE4C | |
| Acetamide SCHEMBL5182479 | 0.91 | BLM (0.35) | CRBNMTNR1APDE4APDE4BPDE4C | |
| SCHEMBL351949 | 0.89 | — | — | |
| SCHEMBL164602 | 0.89 | — | — | |
| SCHEMBL164603 | 0.89 | — | — | |
| Hydrochloric Acid SCHEMBL20532011 | 0.86 | — | — | |
| Acetic Acid SCHEMBL31135264 | 0.74 | PDE4A (0.33) | CRBNITGB3ITGB2ITGB1ITGAV | |
| SCHEMBL17865758 | 0.72 | CRBN (0.59) | CRBN | |
| SCHEMBL16139775 | 0.71 | — | — | |
| Ammonia Solution, Strong SCHEMBL2888472 | 0.71 | GABRP (0.42) | ITGB3ITGB2ITGB1ITGAVITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110551052-A | Preparation method of (R) -4-hydroxy-2-oxo-1-pyrrolidine acetate | CHONGQING RUNZE PHARMACEUTICAL | 2019-12-10 | — | — | CN | claimed |
| CN-110551053-A | preparation method of dextro-oxypyr-mepyramine | CHONGQING RUNZE PHARMACEUTICAL | 2019-12-10 | — | — | CN | claimed |
| EP-0207681-A2 | Pyrrolidone derivatives | ISF SOCIETA PER AZIONI (IT) | 1987-01-07 | — | — | EP | claimed |
| CN-110551052-A | Preparation method of (R) -4-hydroxy-2-oxo-1-pyrrolidine acetate | CHONGQING RUNZE PHARMACEUTICAL | 2019-12-10 | — | — | CN | disclosed |
| CN-110551052-A | Preparation method of (R) -4-hydroxy-2-oxo-1-pyrrolidine acetate | CHONGQING RUNZE PHARMACEUTICAL | 2019-12-10 | — | — | CN | disclosed |
| CN-110551052-A | Preparation method of (R) -4-hydroxy-2-oxo-1-pyrrolidine acetate | CHONGQING RUNZE PHARMACEUTICAL | 2019-12-10 | — | — | CN | disclosed |
| CN-110551053-A | preparation method of dextro-oxypyr-mepyramine | CHONGQING RUNZE PHARMACEUTICAL | 2019-12-10 | — | — | CN | disclosed |
| CN-110551053-A | preparation method of dextro-oxypyr-mepyramine | CHONGQING RUNZE PHARMACEUTICAL | 2019-12-10 | — | — | CN | disclosed |
| CN-106397294-A | Preparation method of nootropic of (S)-oxiracetam | 山东默得森生物制药有限公司 | 2017-02-15 | — | — | CN | disclosed |
| CN-102432516-A | Refining method of oxiracetam | SHANDONG ARURA PHARMACEUTICAL RES & DEV CO LTD | 2012-05-02 | — | — | CN | disclosed |
| US-5371237-A | Process for the production of 4-hydroxy-2-oxopyrrolidin-1-yl-acetamide | LONZA LTD. (CH) | 1994-12-06 | — | — | US | disclosed |
| US-5276164-A | Process for the production of 4-hydroxy-2-oxopyrrolidin-1-yl-acetamide | LONZA LTD. (CH) | 1994-01-04 | — | — | US | disclosed |
| EP-0207680-A2 | Chemical compounds | ISF SOCIETA PER AZIONI (IT) | 1987-01-07 | — | — | EP | disclosed |