SCHEMBL9302312

SCHEMBL9302312

CC(C)(C)c1nc(-c2cccnc2)nc(C(C)(C)C)c1O

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 1/20 0.49
ALDH1A1 P00352 4/20 0.48
SMN1; SMN2 Q16637 3/20 0.48
HSD17B10 Q99714 2/20 0.48
LMNA P02545 2/20 0.48
MAPT P10636 2/20 0.48
TP53 P04637 2/20 0.48
KDM4E B2RXH2 1/20 0.48
HPGD P15428 1/20 0.48
ALOX15 P16050 1/20 0.48
HTT P42858 1/20 0.48
CYP2A6 P11509 3/20 0.47
CYP1A2 P05177 5/20 0.45
CYP3A4 P08684 4/20 0.45
CYP2C9 P11712 3/20 0.45
CYP2C19 P33261 2/20 0.45
NPSR1 Q6W5P4 3/20 0.44
TSHR P16473 2/20 0.44
CHRNB2 P17787 1/20 0.44
CHRNA5 P30532 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9539358 0.83 CYP3A4 (0.48) KIF11ALDH1A1SMN1; SMN2HSD17B10LMNA
SCHEMBL9431602 0.79 KIF11 (0.44) KIF11LMNAMAPTTP53HPGD
SCHEMBL19977476 0.77 ALDH1A1 (0.53) KIF11ALDH1A1SMN1; SMN2HSD17B10LMNA
SCHEMBL5489470 0.76 KIF11 (0.45) KIF11ALDH1A1SMN1; SMN2HSD17B10LMNA
SCHEMBL5032444 0.75 SMN1; SMN2 (0.73) ALDH1A1SMN1; SMN2HSD17B10LMNAMAPT
SCHEMBL29543568 0.75 SMN1; SMN2 (0.73) ALDH1A1SMN1; SMN2HSD17B10LMNAMAPT
SCHEMBL9301523 0.75 TDP1 (0.40) ALDH1A1SMN1; SMN2LMNAMAPTCYP1A2
SCHEMBL20805743 0.75 KIF11 (0.74) KIF11ALDH1A1SMN1; SMN2HSD17B10LMNA
SCHEMBL19735248 0.75 KIF11 (0.74) KIF11ALDH1A1SMN1; SMN2HSD17B10LMNA
SCHEMBL9425993 0.74 NPC1 (0.44) KIF11ALDH1A1SMN1; SMN2MAPTKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5177079-A Antiallergen, antiulcer WARNER-LAMBERT COMPANY (US) 1993-01-05 US claimed
US-5340815-A Inhibitors of 5-lipoxygenase and/or cyclooxygenase WARNER-LAMBERT COMPANY (US) 1994-08-23 US disclosed
US-5302597-A Enzyme inhibitors WARNER-LAMBERT COMPANY (US) 1994-04-12 US disclosed
EP-0569491-A4 2-SUBSTITUTED-4,6-DI-TERTIARY-BUTYL-5-HYDROXY-1,3-PYRIMIDINES USEFUL AS ANTIINFLAMMATORY AGENTS 1993-11-24 EP disclosed
EP-0569491-A1 2-SUBSTITUTED-4,6-DI-TERTIARY-BUTYL-5-HYDROXY-1,3-PYRIMIDINES USEFUL AS ANTIINFLAMMATORY AGENTS WARNER-LAMBERT COMPANY (US) 1993-11-18 EP disclosed
US-5248682-A Inhibitors of lipoxygenase and cyclooxygenase WARNER-LAMBERT COMPANY (US) 1993-09-28 US disclosed
US-5177079-A Antiallergen, antiulcer WARNER-LAMBERT COMPANY (US) 1993-01-05 US disclosed
WO-1992013536-A1 2-SUBSTITUTED-4,6-DI-TERTIARY-BUTYL-5-HYDROXY-1,3-PYRIMIDINES USEFUL AS ANTIINFLAMMATORY AGENTS WARNER-LAMBERT COMPANY (US) 1992-08-20 WO disclosed