Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2D | O15399 | 1/20 | 0.41 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.41 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA3 | P07451 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | CA6 | P23280 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.36 |
| ▸ | GPR35 | Q9HC97 | 3/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.36 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9303051 | 0.91 | CA12 (0.45) | GRIN2DGRIN2AGRIN2BGRIN2CFOLH1 | |
| SCHEMBL9302726 | 0.83 | PTPN1 (0.48) | GRIN2DGRIN2AGRIN2BGRIN2CGPR35 | |
| SCHEMBL9242812 | 0.83 | GRIN2D (0.44) | GRIN2DGRIN2AGRIN2BGRIN2CGPR35 | |
| SCHEMBL9301998 | 0.78 | P2RY14 (0.61) | MEN1KMT2AMAOBP2RY14KDM4E | |
| SCHEMBL9303741 | 0.77 | MEN1 (0.52) | MEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL9302396 | 0.74 | HSD11B1 (0.39) | GRIN2DGRIN2AGRIN2BGRIN2CGPR35 | |
| SCHEMBL9303171 | 0.73 | POLB (0.43) | GRIN2DGRIN2AGRIN2BGRIN2CGPR35 | |
| SCHEMBL9302205 | 0.72 | ESR1 (0.44) | GRIN2DGRIN2AGRIN2BGRIN2CCA12 | |
| SCHEMBL9302889 | 0.72 | ESR1 (0.41) | GPR35KDM4ESMN1; SMN2 | |
| SCHEMBL6777102 | 0.71 | PTPN1 (0.53) | FOLH1PTPN1PTPN2PTPN6CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5281720-A | Antiasthmatics, antiallergens, antiinflammatory agents and cytoprotective agents | MERCK FROSST CANADA, INC. | 1994-01-25 | — | — | US | disclosed |
| US-5227399-A | Pyranylphenyl naphthalene lactones as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA, INC. (CA) | 1993-07-13 | — | — | US | disclosed |
| EP-0501579-A1 | Naphthalene lactones as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1992-09-02 | — | — | EP | disclosed |
| EP-0501578-A1 | Pyranylphenyl hydroxyalkylnaphthoic acids as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1992-09-02 | — | — | EP | disclosed |