Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.41 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.38 |
| ▸ | KMO | O15229 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9303741 | 0.87 | MEN1 (0.52) | PDE4BPDE4DKDM4EALDH1A1HPGD | |
| SCHEMBL9242812 | 0.86 | GRIN2D (0.44) | PTPN1GRIN2DGRIN2AGRIN2BGRIN2C | |
| SCHEMBL9303051 | 0.86 | CA12 (0.45) | PTPN1P2RY14GRIN2DGRIN2AGRIN2B | |
| SCHEMBL9302447 | 0.83 | GRIN2D (0.41) | PTPN1P2RY14GRIN2DGRIN2AGRIN2B | |
| SCHEMBL9301998 | 0.79 | P2RY14 (0.61) | P2RY14KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL9448663 | 0.78 | PTPN1 (0.58) | PTPN1GRIN2DGRIN2AGRIN2CKDM4E | |
| SCHEMBL9302396 | 0.77 | HSD11B1 (0.39) | PTPN1P2RY14GRIN2DGRIN2AGRIN2B | |
| SCHEMBL9303171 | 0.76 | POLB (0.43) | GRIN2DGRIN2AGRIN2BGRIN2CPOLB | |
| SCHEMBL5189717 | 0.75 | P2RY14 (0.44) | PTPN1P2RY14KDM4ENPC1ALDH1A1 | |
| SCHEMBL9302889 | 0.75 | ESR1 (0.41) | KDM4ENPC1ALDH1A1GAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5281720-A | Antiasthmatics, antiallergens, antiinflammatory agents and cytoprotective agents | MERCK FROSST CANADA, INC. | 1994-01-25 | — | — | US | disclosed |
| US-5227399-A | Pyranylphenyl naphthalene lactones as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA, INC. (CA) | 1993-07-13 | — | — | US | disclosed |
| EP-0501579-A1 | Naphthalene lactones as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1992-09-02 | — | — | EP | disclosed |
| EP-0501578-A1 | Pyranylphenyl hydroxyalkylnaphthoic acids as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1992-09-02 | — | — | EP | disclosed |