Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 13/20 | 0.67 |
| ▸ | RARG | P13631 | 13/20 | 0.67 |
| ▸ | RARA | P10276 | 12/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.56 |
| ▸ | RXRA | P19793 | 2/20 | 0.39 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8664187 | 0.90 | RARA (0.55) | RARBRARGRARACYP3A4KMT2A | |
| SCHEMBL19342900 | 0.88 | RARB (0.72) | RARBRARGRARACYP3A4KMT2A | |
| SCHEMBL6665899 | 0.88 | RARB (0.62) | RARBRARGRARACYP3A4KMT2A | |
| SCHEMBL6665585 | 0.86 | CYP3A4 (0.64) | RARBRARGRARACYP3A4KMT2A | |
| SCHEMBL9304096 | 0.86 | RARA (0.51) | RARBRARGRARACYP3A4KMT2A | |
| SCHEMBL8864910 | 0.85 | RARA (0.49) | RARBRARGRARACYP3A4KMT2A | |
| SCHEMBL9303234 | 0.85 | RARB (0.61) | RARBRARGRARACYP3A4KMT2A | |
| SCHEMBL19342899 | 0.84 | RARB (0.79) | RARBRARGRARACYP3A4KMT2A | |
| SCHEMBL9817758 | 0.84 | RARA (0.62) | RARBRARGRARACYP3A4KMT2A | |
| SCHEMBL9303919 | 0.83 | RARA (0.64) | RARBRARGRARACYP3A4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5354752-A | A dimethylthiochroman or dimethylchroman-6-yl-ethynyl-pyridazin- or pyrimidin- or pyrazin-for treating skin disorders psoriasis | ALLERGAN, INC. (US) | 1994-10-11 | — | — | US | claimed |