Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9303658 | 0.90 | — | — | |
| SCHEMBL9301245 | 0.89 | — | — | |
| SCHEMBL9303247 | 0.86 | CYP3A4 (0.35) | NPC1MAPTRAB9ASMN1; SMN2NPSR1 | |
| SCHEMBL9304106 | 0.86 | NPC1 (0.33) | NPC1MAPTRAB9ASMN1; SMN2NPSR1 | |
| SCHEMBL9817718 | 0.84 | FDFT1 (0.38) | NPC1MAPTRAB9ASMN1; SMN2NPSR1 | |
| SCHEMBL9301562 | 0.84 | NPC1 (0.35) | NPC1MAPTRAB9ASMN1; SMN2NPSR1 | |
| SCHEMBL9304331 | 0.80 | RXRA (0.36) | NPC1MAPTRAB9ASMN1; SMN2NPSR1 | |
| SCHEMBL6667778 | 0.79 | NPC1 (0.31) | NPC1MAPTRAB9ASMN1; SMN2NPSR1 | |
| SCHEMBL9817790 | 0.78 | MAPT (0.38) | NPC1MAPTRAB9ASMN1; SMN2NPSR1 | |
| SCHEMBL6668356 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5354752-A | A dimethylthiochroman or dimethylchroman-6-yl-ethynyl-pyridazin- or pyrimidin- or pyrazin-for treating skin disorders psoriasis | ALLERGAN, INC. (US) | 1994-10-11 | — | — | US | claimed |