Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 2/20 | 0.54 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.54 |
| ▸ | MAOB | P27338 | 4/20 | 0.53 |
| ▸ | PTGES | O14684 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.50 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.50 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.48 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9304203 | 0.91 | MAOB (0.48) | SRD5A2NR4A2MAOBPTGESSMN1; SMN2 | |
| SCHEMBL5119495 | 0.83 | SRD5A2 (0.59) | SRD5A2NR4A2MAOBPTGESSMN1; SMN2 | |
| SCHEMBL29481015 | 0.83 | MAOB (0.71) | SRD5A2NR4A2MAOBPTGESSMN1; SMN2 | |
| SCHEMBL26863 | 0.83 | MAOB (0.71) | SRD5A2NR4A2MAOBPTGESSMN1; SMN2 | |
| Benzophenone SCHEMBL28215327 | 0.82 | MAOB (0.69) | SRD5A2NR4A2MAOBPTGESSMN1; SMN2 | |
| SCHEMBL14315506 | 0.81 | SRD5A2 (0.60) | SRD5A2NR4A2MAOBPTGESSMN1; SMN2 | |
| SCHEMBL8618024 | 0.81 | SRD5A2 (0.57) | SRD5A2NR4A2MAOBPTGESSMN1; SMN2 | |
| SCHEMBL8408190 | 0.81 | MEN1 (0.63) | MAOBALDH1A1MAOAL3MBTL1MEN1 | |
| SCHEMBL7383227 | 0.80 | TUBB1 (0.53) | MAOBSMN1; SMN2ALDH1A1 | |
| SCHEMBL8327914 | 0.79 | MAOA (0.61) | MAOBMAOAMEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5281720-A | Antiasthmatics, antiallergens, antiinflammatory agents and cytoprotective agents | MERCK FROSST CANADA, INC. | 1994-01-25 | — | — | US | disclosed |
| US-5227399-A | Pyranylphenyl naphthalene lactones as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA, INC. (CA) | 1993-07-13 | — | — | US | disclosed |
| EP-0501579-A1 | Naphthalene lactones as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1992-09-02 | — | — | EP | disclosed |
| EP-0501578-A1 | Pyranylphenyl hydroxyalkylnaphthoic acids as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1992-09-02 | — | — | EP | disclosed |