Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.43 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.43 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5872160 | 0.83 | HTT (0.51) | POLBHTTGAAMAPTKMT2A | |
| SCHEMBL27485980 | 0.80 | KMT2A (0.49) | MAPTKMT2AALDH1A1F2PRSS1 | |
| SCHEMBL22163994 | 0.79 | KMT2A (0.48) | POLBHTTGAAMAPTKMT2A | |
| SCHEMBL28498471 | 0.79 | HTT (0.57) | POLBHTTKMT2AALDH1A1TSHR | |
| SCHEMBL27519584 | 0.78 | KMT2A (0.50) | MAPTKMT2AALDH1A1F2PRSS1 | |
| SCHEMBL11722467 | 0.77 | GAA (0.54) | POLBHTTGAAMAPTKMT2A | |
| Hydrochloric Acid SCHEMBL27483889 | 0.76 | KMT2A (0.49) | MAPTKMT2AALDH1A1F2PRSS1 | |
| SCHEMBL8078609 | 0.75 | HTT (0.57) | POLBHTTGAAMAPTKMT2A | |
| SCHEMBL6141208 | 0.75 | HTR2A (0.64) | HTTGAAMAPTALDH1A1RAB9A | |
| SCHEMBL1425402 | 0.74 | LOXL2 (0.57) | POLBHTTGAAMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5360802-A | Antagonists of cholecystokinin and gastrin | MERCK SHARPE & DOHME LTD. | 1994-11-01 | — | — | US | disclosed |
| EP-0514133-A1 | Benzodiazepine derivatives, compositions containing them and their use in therapy | MERCK SHARP & DOHME LTD. (GB) | 1992-11-19 | — | — | EP | disclosed |