Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 4/20 | 0.57 |
| ▸ | RAB9A | P51151 | 4/20 | 0.57 |
| ▸ | TP53 | P04637 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | CDYL2 | Q8N8U2 | 1/20 | 0.57 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.57 |
| ▸ | CDY1; CDY1B | Q9Y6F8 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.55 |
| ▸ | IDO1 | P14902 | 4/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9304188 | 0.88 | HDAC1 (0.59) | HDAC1HDAC6NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9304316 | 0.85 | HDAC1 (0.66) | HDAC1HDAC6NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3497107 | 0.78 | HDAC1 (0.70) | HDAC1HDAC6RAB9ASMN1; SMN2LMNA | |
| SCHEMBL16147971 | 0.77 | CYP11B1 (0.69) | SMN1; SMN2LMNATSHRCDYL2CDYL | |
| SCHEMBL16147363 | 0.77 | FGFR1 (0.62) | NPC1RAB9ATP53SMN1; SMN2MAPT | |
| SCHEMBL14376802 | 0.77 | HDAC6 (0.53) | HDAC1HDAC6NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL14376815 | 0.77 | HDAC6 (0.65) | HDAC1HDAC6MMP13 | |
| SCHEMBL17946096 | 0.77 | MAPT (0.86) | NPC1RAB9ATP53SMN1; SMN2LMNA | |
| SCHEMBL12850040 | 0.77 | HDAC6 (1.00) | HDAC1HDAC6SMN1; SMN2LMNAIDO1 | |
| SCHEMBL12771538 | 0.76 | HTT (0.72) | HDAC1HDAC6SMN1; SMN2LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0468971-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1992-02-05 | — | — | EP | claimed |
| WO-1990009997-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1990-09-07 | — | — | WO | claimed |
| US-5314880-A | Platelet activating factor antagonist | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1994-05-24 | — | — | US | disclosed |
| EP-0468971-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1992-02-05 | — | — | EP | disclosed |
| WO-1990009997-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1990-09-07 | — | — | WO | disclosed |