Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY14 | Q15391 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 4/20 | 0.42 |
| ▸ | ANO1 | Q5XXA6 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MDH2 | P40926 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | EDNRA | P25101 | 1/20 | 0.41 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.41 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9303553 | 0.84 | P2RY14 (0.51) | P2RY14CASP3SENP8SENP7SENP6 | |
| SCHEMBL9302893 | 0.82 | P2RY14 (0.42) | P2RY14CASP3SENP8SENP7SENP6 | |
| SCHEMBL9301998 | 0.74 | P2RY14 (0.61) | P2RY14MAOBALDH1A1HPGDMDH2 | |
| SCHEMBL9627496 | 0.72 | CASP3 (0.48) | CASP3SENP8SENP7SENP6MAOB | |
| SCHEMBL9303016 | 0.72 | P2RY14 (0.61) | P2RY14CASP3SENP8SENP7SENP6 | |
| SCHEMBL9304278 | 0.71 | P2RY14 (0.51) | P2RY14CASP3SENP8SENP7SENP6 | |
| SCHEMBL9302951 | 0.70 | P2RY14 (0.56) | P2RY14CASP3SENP8SENP7SENP6 | |
| SCHEMBL9627356 | 0.70 | MAOB (0.48) | CASP3SENP8SENP7SENP6MAOB | |
| SCHEMBL9301951 | 0.70 | P2RY14 (0.55) | P2RY14MAOB | |
| SCHEMBL9305354 | 0.69 | P2RY14 (0.60) | P2RY14MAOBALDH1A1HPGDMDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5281720-A | Antiasthmatics, antiallergens, antiinflammatory agents and cytoprotective agents | MERCK FROSST CANADA, INC. | 1994-01-25 | — | — | US | disclosed |
| US-5227399-A | Pyranylphenyl naphthalene lactones as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA, INC. (CA) | 1993-07-13 | — | — | US | disclosed |
| EP-0501579-A1 | Naphthalene lactones as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1992-09-02 | — | — | EP | disclosed |
| EP-0501578-A1 | Pyranylphenyl hydroxyalkylnaphthoic acids as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1992-09-02 | — | — | EP | disclosed |