Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY14 | Q15391 | 1/20 | 0.55 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.54 |
| ▸ | PDE5A | O76074 | 1/20 | 0.51 |
| ▸ | PDE4A | P27815 | 1/20 | 0.51 |
| ▸ | PDE1A | P54750 | 1/20 | 0.51 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.51 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.51 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 2/20 | 0.42 |
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9304278 | 0.85 | P2RY14 (0.51) | P2RY14ALOX5PDE5APDE4APDE1A | |
| SCHEMBL9301998 | 0.84 | P2RY14 (0.61) | P2RY14ALOX5MAOB | |
| SCHEMBL9303016 | 0.84 | P2RY14 (0.61) | P2RY14ALOX5MAOB | |
| SCHEMBL9304415 | 0.82 | P2RY14 (0.44) | P2RY14ALOX5PDE5APDE4APDE1A | |
| SCHEMBL9302951 | 0.82 | P2RY14 (0.56) | P2RY14ALOX5MAOBBCHEMAOA | |
| SCHEMBL9303779 | 0.78 | P2RY14 (0.50) | P2RY14ALOX5MAOBBCHEMAOA | |
| SCHEMBL9304408 | 0.75 | P2RY14 (0.42) | P2RY14ALOX5MAOBMAOAACHE | |
| SCHEMBL9305354 | 0.74 | P2RY14 (0.60) | P2RY14ALOX5MAOB | |
| SCHEMBL9303553 | 0.74 | P2RY14 (0.51) | P2RY14ALOX5MAOBMAPT | |
| SCHEMBL9301064 | 0.72 | ALOX5 (0.51) | P2RY14ALOX5MAOBMAOAACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5281720-A | Antiasthmatics, antiallergens, antiinflammatory agents and cytoprotective agents | MERCK FROSST CANADA, INC. | 1994-01-25 | — | — | US | disclosed |
| US-5227399-A | Pyranylphenyl naphthalene lactones as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA, INC. (CA) | 1993-07-13 | — | — | US | disclosed |
| EP-0501579-A1 | Naphthalene lactones as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1992-09-02 | — | — | EP | disclosed |
| EP-0501578-A1 | Pyranylphenyl hydroxyalkylnaphthoic acids as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1992-09-02 | — | — | EP | disclosed |