SCHEMBL9303516

SCHEMBL9303516

NC(=O)C(c1ccc(OCc2ccc3ccccc3n2)cc1)C1CCCCCC1

nearest known ligand 0.83

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 20/20 0.83
HDAC6 Q9UBN7 1/20 0.81

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9302919 0.99 ALOX5 (0.82) ALOX5HDAC6
SCHEMBL9123409 0.91 ALOX5 (1.00) ALOX5HDAC6
SCHEMBL7818344 0.91 ALOX5 (1.00) ALOX5HDAC6
SCHEMBL9030094 0.91 ALOX5 (1.00) ALOX5HDAC6
SCHEMBL2110833 0.91 ALOX5 (1.00) ALOX5HDAC6
SCHEMBL2109295 0.91 ALOX5 (1.00) ALOX5HDAC6
SCHEMBL9123415 0.91 ALOX5 (1.00) ALOX5HDAC6
SCHEMBL7818529 0.91 ALOX5 (1.00) ALOX5HDAC6
SCHEMBL9122076 0.91 ALOX5 (1.00) ALOX5HDAC6
SCHEMBL9301897 0.90 ALOX5 (0.77) ALOX5HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5310744-A Antiinflammatory BAYER AKTIENGESELLSCHAFT (DE) 1994-05-10 US claimed
US-5310744-A Antiinflammatory BAYER AKTIENGESELLSCHAFT (DE) 1994-05-10 US disclosed
US-5288733-A Quinolylmethoxyphenylacetic acid acylamides and ureas BAYER AKTIENGESELLSCHAFT (DE) 1994-02-22 US disclosed
US-5283252-A Thiazolyl-substituted quinolylmethoxyphenylacetic acid derivatives BAYER AKTIENGESELLSCHAFT (DE) 1994-02-01 US disclosed
EP-0549879-A2 Thiazol substituted quinolylmethoxyphenylacetic acid derivatives BAYER AG (DE) 1993-07-07 EP disclosed