Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY14 | Q15391 | 1/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.47 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.44 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 6/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 2/20 | 0.39 |
| ▸ | MAOA | P21397 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.39 |
| ▸ | CTSV | O60911 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9302836 | 0.87 | P2RY14 (0.51) | P2RY14ALOX5LTB4RLTB4R2MAOB | |
| SCHEMBL9303174 | 0.84 | P2RY14 (0.41) | P2RY14ALOX5LTB4RLTB4R2MAOB | |
| SCHEMBL9302951 | 0.81 | P2RY14 (0.56) | P2RY14ALOX5LTB4RLTB4R2MAOB | |
| SCHEMBL9304278 | 0.79 | P2RY14 (0.51) | P2RY14ALOX5LTB4RLTB4R2MAOB | |
| SCHEMBL9303016 | 0.79 | P2RY14 (0.61) | P2RY14ALOX5LTB4RLTB4R2MAOB | |
| SCHEMBL9303192 | 0.79 | P2RY14 (0.41) | P2RY14ALOX5LTB4RLTB4R2MAOB | |
| SCHEMBL9301951 | 0.78 | P2RY14 (0.55) | P2RY14ALOX5MAOBBCHEMAOA | |
| SCHEMBL9301696 | 0.76 | P2RY14 (0.55) | P2RY14ALOX5LTB4RLTB4R2MAOB | |
| SCHEMBL9127224 | 0.74 | ALOX5 (0.54) | ALOX5MAOBCYP3A4SRD5A2 | |
| SCHEMBL9301998 | 0.73 | P2RY14 (0.61) | P2RY14ALOX5MAOBSRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5281720-A | Antiasthmatics, antiallergens, antiinflammatory agents and cytoprotective agents | MERCK FROSST CANADA, INC. | 1994-01-25 | — | — | US | disclosed |
| US-5227399-A | Pyranylphenyl naphthalene lactones as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA, INC. (CA) | 1993-07-13 | — | — | US | disclosed |
| EP-0501579-A1 | Naphthalene lactones as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1992-09-02 | — | — | EP | disclosed |
| EP-0501578-A1 | Pyranylphenyl hydroxyalkylnaphthoic acids as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1992-09-02 | — | — | EP | disclosed |