Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 4/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | SGMS2 | Q8NHU3 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | LIPE | Q05469 | 1/20 | 0.40 |
| ▸ | RXRA | P19793 | 2/20 | 0.40 |
| ▸ | RXRB | P28702 | 2/20 | 0.40 |
| ▸ | RXRG | P48443 | 2/20 | 0.40 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetonitrile SCHEMBL9303477 | 0.80 | SLC6A4 (0.41) | MAPTMAPK1TDP1L3MBTL1HTR1A | |
| SCHEMBL5016341 | 0.79 | RXRB (0.48) | MAPTMAPK1TDP1L3MBTL1HTR1A | |
| SCHEMBL26923037 | 0.75 | ALDH1A1 (0.44) | MAPTL3MBTL1HTR1ASLC6A2SLC6A4 | |
| SCHEMBL10256201 | 0.72 | HRH3 (0.46) | HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2857359 | 0.72 | HTR6 (0.52) | SLC6A4HTR6MAOAMAOBSGMS2 | |
| Ammonia Solution, Strong SCHEMBL27980687 | 0.71 | MAPT (0.55) | MAPTMAPK1TDP1L3MBTL1HTR1A | |
| SCHEMBL30973516 | 0.71 | RXRB (0.58) | MAPTMAPK1TDP1L3MBTL1HTR1A | |
| SCHEMBL22632798 | 0.71 | RXRB (0.58) | MAPTMAPK1TDP1L3MBTL1HTR1A | |
| Hydrochloric Acid SCHEMBL3798819 | 0.71 | HTR6 (0.51) | SLC6A4HTR6MAOAMAOBRXRA | |
| SCHEMBL30101569 | 0.71 | HRH3 (0.45) | MAPK1HTR1ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5310750-A | Heterocyclic compounds useful as α2 -adrenoceptor antagonists | BEECHAM GROUP P.L.C. (GB) | 1994-05-10 | — | — | US | disclosed |
| EP-0313288-B1 | IMIDAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ALPHA 2-ADRENO-RECEPTOR ANTAGONISTS | BEECHAM GROUP PLC (GB) | 1992-12-30 | — | — | EP | disclosed |
| US-5021445-A | Hyperglycemic and hypertensive agents; anticoagulants, alpha2-adrenoceptor antagonists | BEECHAM GROUP P.L.C. (GB) | 1991-06-04 | — | — | US | disclosed |
| EP-0313288-A1 | Imidazole derivatives, process for their preparation and their use as alpha 2-adreno-receptor antagonists | BEECHAM GROUP PLC (GB) | 1989-04-26 | — | — | EP | disclosed |