Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.49 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 1/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 9/20 | 0.69 |
| ▸ | DRD3 | P35462 | 4/20 | 0.61 |
| ▸ | DRD2 | P14416 | 4/20 | 0.61 |
| ▸ | DRD4 | P21917 | 2/20 | 0.61 |
| ▸ | FYN | P06241 | 1/20 | 0.61 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.59 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL9303647 | 1.00 | GRIN2B (0.69) | GRIN2BDRD3DRD2DRD4FYN | |
| Bromide SCHEMBL9304413 | 1.00 | GRIN2B (0.69) | GRIN2BDRD3DRD2DRD4FYN | |
| SCHEMBL9304253 | 0.99 | GRIN2B (0.71) | GRIN2BDRD3DRD2DRD4FYN | |
| SCHEMBL6133948 | 0.99 | GRIN2B (0.71) | GRIN2BDRD3DRD2DRD4FYN | |
| SCHEMBL9306071 | 0.99 | GRIN2B (0.71) | GRIN2BDRD3DRD2DRD4FYN | |
| SCHEMBL5142005 | 0.91 | GRIN2B (0.59) | GRIN2BDRD3DRD2DRD4FYN | |
| SCHEMBL8765625 | 0.91 | GRIN2B (0.59) | GRIN2BDRD3DRD2DRD4FYN | |
| SCHEMBL8765804 | 0.90 | GRIN2B (0.58) | GRIN2BDRD3DRD2DRD4FYN | |
| Hydrochloric Acid SCHEMBL8765161 | 0.90 | GRIN2B (0.58) | GRIN2BDRD3DRD2DRD4FYN | |
| Hydrochloric Acid SCHEMBL5144064 | 0.90 | GRIN2B (0.58) | GRIN2BDRD3DRD2DRD4FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5312961-A | 2-amino-7-hydroxytetralin carboxylalkyl ethers | ELF SANOFI (FR) | 1994-05-17 | — | — | US | disclosed |
| US-5202466-A | 2-amino-7-hydroxytetraline ethers | SANOFI (FR) | 1993-04-13 | — | — | US | disclosed |
| US-5159103-A | 2-amino-7-hydroxytetraline ethers | SANOFI (FR) | 1992-10-27 | — | — | US | disclosed |