Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | ACHE | P22303 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | TTR | P02766 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.42 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6364662 | 0.82 | LMNA (0.52) | LMNAACHEKDM4EMAPTCYP3A4 | |
| SCHEMBL3688841 | 0.80 | LMNA (0.50) | LMNAACHEKDM4EMAPTCYP3A4 | |
| SCHEMBL23809728 | 0.80 | BACE1 (0.52) | LMNAACHEKDM4EMAPTCYP3A4 | |
| SCHEMBL27523775 | 0.78 | TSHR (0.54) | LMNAACHEKDM4EMAPTCYP3A4 | |
| SCHEMBL204814 | 0.78 | LMNA (0.48) | LMNAACHEKDM4EMAPTCYP3A4 | |
| SCHEMBL1257132 | 0.78 | CYP4F2 (0.50) | LMNAACHEKDM4EMAPTCYP3A4 | |
| SCHEMBL2010436 | 0.78 | LMNA (0.59) | LMNAACHEKDM4EMAPTCYP3A4 | |
| SCHEMBL7586397 | 0.77 | LMNA (0.50) | LMNAACHEKDM4EMAPTCYP3A4 | |
| SCHEMBL10477434 | 0.77 | CYP4F2 (0.44) | LMNAACHEKDM4EMAPTCYP3A4 | |
| SCHEMBL10834970 | 0.77 | HSD17B10 (0.53) | LMNAACHEKDM4EMAPTCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5364850-A | Analgesics | G. D. SEARLE & CO. (US) | 1994-11-15 | — | — | US | disclosed |
| US-5272175-A | Substituted tyrosyl diamide compounds | G. D. SEARLE & CO. (US) | 1993-12-21 | — | — | US | disclosed |