Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9306854 | 0.88 | HPGD (0.45) | CNR1CNR2EPHX2NPSR1MEN1 | |
| Iodide SCHEMBL9307156 | 0.85 | HSD17B10 (0.57) | CNR1CNR2EPHX2NPSR1MEN1 | |
| Iodide SCHEMBL9309538 | 0.85 | HSD17B10 (0.57) | CNR1CNR2EPHX2NPSR1MEN1 | |
| Iodide SCHEMBL9305452 | 0.83 | CNR1 (0.47) | CNR1CNR2EPHX2NPSR1 | |
| Iodide SCHEMBL9306630 | 0.83 | CNR1 (0.47) | CNR1CNR2EPHX2NPSR1 | |
| Iodide SCHEMBL9307849 | 0.82 | CNR1 (0.39) | CNR1CNR2EPHX2NPSR1 | |
| Iodide SCHEMBL9307184 | 0.80 | S1PR2 (0.46) | CNR1CNR2EPHX2NPSR1MEN1 | |
| Iodide SCHEMBL9307883 | 0.80 | S1PR2 (0.46) | CNR1CNR2EPHX2NPSR1MEN1 | |
| Iodide SCHEMBL9307642 | 0.80 | NPSR1 (0.44) | CNR1CNR2NPSR1MEN1NPC1 | |
| Iodide SCHEMBL9309311 | 0.80 | HSD17B10 (0.55) | CNR1CNR2EPHX2NPSR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328921-A | Antagonist of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1994-07-12 | — | — | US | disclosed |