Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.38 |
| ▸ | PTGES | O14684 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | APAF1 | O14727 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9306140 | 0.91 | CNR2 (0.41) | CNR1CNR2EPHX2ALDH1A1NPSR1 | |
| Iodide SCHEMBL9306570 | 0.87 | NPSR1 (0.43) | CNR1CNR2ALDH1A1LMNAMAPT | |
| Iodide SCHEMBL9308377 | 0.85 | CNR2 (0.41) | CNR1CNR2EPHX2ALDH1A1NPSR1 | |
| Iodide SCHEMBL9305282 | 0.84 | S1PR2 (0.45) | CNR1CNR2EPHX2KDM4EAPAF1 | |
| Iodide SCHEMBL9306863 | 0.84 | S1PR2 (0.45) | CNR1CNR2EPHX2KDM4EAPAF1 | |
| Iodide SCHEMBL9306014 | 0.83 | CNR2 (0.41) | CNR2EPHX2KDM4ELMNANPSR1 | |
| Iodide SCHEMBL9306323 | 0.83 | CNR2 (0.41) | CNR2EPHX2KDM4ELMNANPSR1 | |
| Iodide SCHEMBL9305590 | 0.82 | CNR1 (0.43) | CNR1CNR2EPHX2NPSR1 | |
| Iodide SCHEMBL9309311 | 0.81 | HSD17B10 (0.55) | CNR1CNR2EPHX2POLBNPSR1 | |
| Iodide SCHEMBL9308444 | 0.81 | CNR1 (0.43) | CNR1CNR2APAF1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328921-A | Antagonist of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1994-07-12 | — | — | US | disclosed |