Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | HTR1D | P28221 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 3/20 | 0.40 |
| ▸ | JAK1 | P23458 | 3/20 | 0.40 |
| ▸ | TYK2 | P29597 | 3/20 | 0.40 |
| ▸ | JAK3 | P52333 | 3/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8653471 | 0.85 | NPC1 (0.46) | HDAC6KMT2AMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL13080227 | 0.83 | HDAC6 (0.40) | HDAC6TP53MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL13080228 | 0.83 | RAB9A (0.42) | HDAC6TP53MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL19029250 | 0.81 | LCK (0.44) | HDAC6LCKKMT2ACHEK2TP53 | |
| SCHEMBL13356595 | 0.80 | RAB9A (0.51) | HDAC6KMT2AMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL28145348 | 0.80 | HDAC6 (0.43) | HDAC6LCKKMT2ACHEK2TP53 | |
| SCHEMBL1101422 | 0.80 | MAPT (0.53) | HDAC6TP53MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL29364250 | 0.80 | MAPT (0.53) | HDAC6TP53MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL5961129 | 0.76 | CA12 (0.48) | KMT2AMAPTRAB9ASMN1; SMN2MEN1 | |
| SCHEMBL25022261 | 0.73 | HDAC6 (0.40) | HDAC6KMT2ATP53MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5347008-A | Thio(cyclo) alkanepolycarboxylic acids containing heterocyclic substituents | CIBA-GEIGY CORPORATION (US) | 1994-09-13 | — | — | US | disclosed |
| EP-0129506-A2 | Heterocyclically substituted thio(cyclo)alkane polycarboxylic acids | CIBA-GEIGY AG (CH) | 1984-12-27 | — | — | EP | disclosed |