Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9306729 | 0.94 | NPSR1 (0.46) | NPSR1LMNAMEN1NR1I2CHRM2 | |
| Iodide SCHEMBL9308377 | 0.86 | CNR2 (0.41) | NPSR1ALDH1A1HPGDCNR2CNR1 | |
| Iodide SCHEMBL9307832 | 0.86 | NPSR1 (0.44) | NPSR1LMNAMEN1NR1I2CHRM2 | |
| Iodide SCHEMBL9306570 | 0.84 | NPSR1 (0.43) | NPSR1LMNAMEN1NR1I2CHRM2 | |
| Iodide SCHEMBL9306612 | 0.83 | NPSR1 (0.46) | NPSR1LMNAMEN1NR1I2CHRM2 | |
| Iodide SCHEMBL9310265 | 0.82 | NPSR1 (0.47) | NPSR1LMNAMEN1NR1I2CHRM2 | |
| Iodide SCHEMBL9312558 | 0.80 | NPSR1 (0.45) | NPSR1LMNAMEN1NR1I2CHRM2 | |
| Iodide SCHEMBL9306140 | 0.80 | CNR2 (0.41) | NPSR1ALDH1A1HPGDCNR2CNR1 | |
| Iodide SCHEMBL9305547 | 0.79 | THRB (0.51) | LMNAALDH1A1THRATHRB | |
| Iodide SCHEMBL9307700 | 0.79 | POLB (0.52) | CNR2THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328921-A | Antagonist of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1994-07-12 | — | — | US | disclosed |