Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9307832 | 0.90 | NPSR1 (0.44) | NPSR1LMNAMEN1NR1I2CHRM2 | |
| Iodide SCHEMBL9306729 | 0.90 | NPSR1 (0.46) | NPSR1LMNAMEN1NR1I2CHRM2 | |
| Iodide SCHEMBL9307849 | 0.87 | CNR1 (0.39) | NPSR1LMNAMAPTALDH1A1CNR2 | |
| Iodide SCHEMBL9306043 | 0.84 | NPSR1 (0.46) | NPSR1LMNAMEN1NR1I2CHRM2 | |
| Iodide SCHEMBL9305752 | 0.82 | THRB (0.47) | MEN1KMT2AALDH1A1THRBGGPS1 | |
| Iodide SCHEMBL9305581 | 0.82 | POLB (0.50) | LMNAALDH1A1CNR2THRBTHRA | |
| Iodide SCHEMBL9306576 | 0.82 | THRB (0.47) | MEN1KMT2AALDH1A1THRBGGPS1 | |
| Iodide SCHEMBL9307637 | 0.82 | POLB (0.50) | LMNAALDH1A1CNR2THRBTHRA | |
| Iodide SCHEMBL9312558 | 0.81 | NPSR1 (0.45) | NPSR1LMNAMEN1NR1I2CHRM2 | |
| Iodide SCHEMBL9306854 | 0.81 | HPGD (0.45) | NPSR1LMNAMEN1NR1I2CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328921-A | Antagonist of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1994-07-12 | — | — | US | disclosed |