SCHEMBL9306232

SCHEMBL9306232

O=C(O)CC(Sc1nc2c(F)cccc2o1)C(=O)O

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DAGLA Q9Y4D2 1/20 0.41
POLB P06746 2/20 0.35
NPSR1 Q6W5P4 1/20 0.35
KDM4E B2RXH2 2/20 0.33
ALDH1A1 P00352 2/20 0.33
APOBEC3G Q9HC16 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
PIK3CD O00329 1/20 0.33
PIK3CB P42338 1/20 0.33
ITGB2 P05107 1/20 0.33
ICAM1 P05362 1/20 0.33
ITGAL P20701 1/20 0.33
SHMT2 P34897 1/20 0.32
GRK6 P43250 2/20 0.32
MEN1 O00255 1/20 0.32
NPC1 O15118 1/20 0.32
HPGD P15428 1/20 0.32
RAB9A P51151 1/20 0.32
KMT2A Q03164 1/20 0.32
CTSA P10619 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9305335 0.83 TOP2A (0.38) POLBNPSR1KDM4EALDH1A1PIK3CD
SCHEMBL8973084 0.83 SOAT1 (0.37)
SCHEMBL9304109 0.82 RAB9A (0.34) POLBNPSR1KDM4EALDH1A1APOBEC3G
SCHEMBL8972330 0.79 KMT2A (0.52) POLBALDH1A1TDP1MEN1NPC1
SCHEMBL9306346 0.78 CYP1A2 (0.36) KDM4EALDH1A1MEN1HPGDKMT2A
SCHEMBL9305147 0.78 NPSR1 (0.42) POLBNPSR1KDM4EALDH1A1GRK6
Ammonia Solution, Strong SCHEMBL10889818 0.78 KMT2A (0.51) POLBALDH1A1TDP1MEN1NPC1
SCHEMBL10895295 0.78 KMT2A (0.51) POLBALDH1A1TDP1MEN1NPC1
SCHEMBL10892974 0.78 NPSR1 (0.43) NPSR1KDM4EALDH1A1PIK3CDPIK3CB
Dimethylamine SCHEMBL10893052 0.75 ALDH1A1 (0.50) POLBALDH1A1TDP1MEN1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5347008-A Thio(cyclo) alkanepolycarboxylic acids containing heterocyclic substituents CIBA-GEIGY CORPORATION (US) 1994-09-13 US disclosed
US-5152929-A Corrosion inhibitors for water systems CIBA-GEIGY CORPORATION (US) 1992-10-06 US disclosed
US-4612049-A BENZOTHI ZOLYL THIO-, BENZIMIDAZOLYLTHIO- OR BENZOXAZOLYLTHIO-SUBSTITUTED CARBOXY ACID CIBA-GEIGY CORPORATION (US) 1986-09-16 US disclosed