Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.42 |
| ▸ | THRA | P10827 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9307428 | 0.92 | MAPT (0.41) | LMNAMAPTHTTSMN1; SMN2L3MBTL1 | |
| Iodide SCHEMBL9307453 | 0.92 | RAF1 (0.50) | MAPT | |
| Iodide SCHEMBL9305821 | 0.92 | MAPT (0.44) | LMNAMAPTHTTSMN1; SMN2L3MBTL1 | |
| Iodide SCHEMBL9307162 | 0.91 | THRA (0.45) | THRATHRB | |
| Iodide SCHEMBL9306025 | 0.90 | THRA (0.42) | THRATHRB | |
| Iodide SCHEMBL9305092 | 0.88 | — | — | |
| Iodide SCHEMBL9306943 | 0.87 | LMNA (0.43) | LMNAMAPTHTTSMN1; SMN2L3MBTL1 | |
| Iodide SCHEMBL9307761 | 0.86 | THRA (0.46) | THRATHRB | |
| Iodide SCHEMBL9306525 | 0.86 | LMNA (0.41) | LMNAMAPTHTTSMN1; SMN2L3MBTL1 | |
| Iodide SCHEMBL9308427 | 0.86 | LMNA (0.42) | LMNAMAPTHTTSMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328921-A | Antagonist of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1994-07-12 | — | — | US | disclosed |