Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | PLK1 | P53350 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9306773 | 0.88 | HPGD (0.56) | HPGDSMN1; SMN2CYP1A2MAPTCYP2C9 | |
| Iodide SCHEMBL9306858 | 0.87 | TSHR (0.49) | LMNA | |
| Iodide SCHEMBL9308472 | 0.84 | POLB (0.51) | — | |
| Iodide SCHEMBL9308127 | 0.84 | POLB (0.51) | — | |
| Iodide SCHEMBL9306973 | 0.84 | SMPD1 (0.55) | — | |
| Iodide SCHEMBL9306961 | 0.84 | SMPD1 (0.55) | — | |
| Iodide SCHEMBL9308269 | 0.84 | THRB (0.48) | SMN1; SMN2MEN1NPC1RAB9AKMT2A | |
| Iodide SCHEMBL9306253 | 0.83 | THRA (0.48) | HPGD | |
| Iodide SCHEMBL9306102 | 0.83 | THRA (0.48) | HPGD | |
| Iodide SCHEMBL9308437 | 0.83 | THRA (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-5213877-A | — | — | None | — | — | JP | disclosed |
| US-5328921-A | Antagonist of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1994-07-12 | — | — | US | disclosed |
| JP-H05213877-A | ARYL, AMIDE, IMIDE AND CARBAMATE PYRIDINE ANTAGONIST OF PLATELET ACTIVATING FACTOR | AMERICAN CYANAMID CO | 1993-08-24 | — | — | JP | disclosed |
| US-5208247-A | Antianaphylactic agents or septic shock | AMERICAN CYANAMID COMPANY (US) | 1993-05-04 | — | — | US | disclosed |
| EP-0530444-A1 | Aryl, amide, imide, and carbamate pyridine antagonists of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1993-03-10 | — | — | EP | disclosed |