Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9306102 | 0.94 | THRA (0.48) | THRATHRBALDH1A1GAAPKM | |
| Iodide SCHEMBL9306253 | 0.94 | THRA (0.48) | THRATHRBALDH1A1GAAPKM | |
| Iodide SCHEMBL9305291 | 0.89 | THRA (0.49) | THRATHRBALDH1A1GAAPKM | |
| Iodide SCHEMBL9308082 | 0.88 | THRB (0.47) | THRATHRBALDH1A1 | |
| Iodide SCHEMBL9307338 | 0.88 | THRB (0.47) | THRATHRBALDH1A1 | |
| Iodide SCHEMBL9305240 | 0.86 | CNR1 (0.47) | THRATHRB | |
| Iodide SCHEMBL9305966 | 0.86 | CNR1 (0.47) | THRATHRB | |
| Iodide SCHEMBL9307398 | 0.84 | THRA (0.52) | THRATHRBALDH1A1GAAPKM | |
| Iodide SCHEMBL9306649 | 0.84 | THRA (0.52) | THRATHRBALDH1A1GAAPKM | |
| Iodide SCHEMBL9307001 | 0.82 | SMPD1 (0.54) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328921-A | Antagonist of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1994-07-12 | — | — | US | disclosed |