Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 1/20 | 0.59 |
| ▸ | PRMT5 | O14744 | 10/20 | 0.57 |
| ▸ | PTGES | O14684 | 1/20 | 0.55 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.55 |
| ▸ | LTC4S | Q16873 | 1/20 | 0.55 |
| ▸ | DHODH | Q02127 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | SCD | O00767 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31289493 | 0.84 | CHEK2 (0.61) | CHEK2PRMT5PTGESALOX5LTC4S | |
| SCHEMBL15455871 | 0.83 | CHEK2 (0.70) | CHEK2PRMT5DHODHKDM4EALDH1A1 | |
| SCHEMBL12470982 | 0.83 | PRMT5 (0.70) | CHEK2PRMT5PTGESALOX5LTC4S | |
| SCHEMBL19432719 | 0.82 | KDM4E (0.55) | CHEK2PRMT5DHODHKDM4ENPC1 | |
| SCHEMBL9306624 | 0.81 | HPSE (0.52) | CHEK2SCDKDM4ENPC1ALDH1A1 | |
| SCHEMBL484162 | 0.81 | CHEK2 (0.57) | CHEK2PRMT5PTGESALOX5LTC4S | |
| SCHEMBL15245146 | 0.80 | DGAT1 (0.58) | CHEK2PRMT5PTGESALOX5LTC4S | |
| SCHEMBL4470392 | 0.78 | NPC1 (0.52) | ALOX5LMNACYP1A2KDM4ENPC1 | |
| SCHEMBL2131853 | 0.78 | XDH (0.55) | ALOX5CYP1A2KDM4ENPC1ALDH1A1 | |
| SCHEMBL9529962 | 0.78 | CYP3A4 (0.54) | ALOX5DHODHCYP1A2KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070004713-A1 | Therapeutic benimidazole compounds | ASTRAZENECA AB (SE) | 2007-01-04 | — | — | US | disclosed |
| EP-1341768-A1 | THERAPEUTIC BENZIMIDAZOLE COMPOUNDS | AstraZeneca AB (SE) | 2003-09-10 | — | — | EP | disclosed |
| WO-2002046168-A1 | THERAPEUTIC BENZIMIDAZOLE COMPOUNDS | ASTRAZENECA AB (SE) | 2002-06-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070004713-A1 | Therapeutic benimidazole compounds | ESR2, ESRRA, ESRRB | CHEK2 3644/4885PRMT5 3509/4885PTGES 670/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.