Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 3/20 | 0.41 |
| ▸ | THRA | P10827 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9305631 | 1.00 | CNR2 (0.41) | CNR2THRATHRBMTNR1AMTNR1B | |
| Iodide SCHEMBL9306709 | 0.92 | TSHR (0.42) | CNR2THRATHRBTSHRRECQL | |
| Iodide SCHEMBL9307072 | 0.92 | TSHR (0.42) | CNR2THRATHRBTSHRRECQL | |
| Iodide SCHEMBL9306494 | 0.91 | MTNR1A (0.41) | CNR2THRATHRBMTNR1ATSHR | |
| Iodide SCHEMBL9308243 | 0.91 | MTNR1A (0.41) | CNR2THRATHRBMTNR1ATSHR | |
| Iodide SCHEMBL9306090 | 0.87 | S1PR2 (0.43) | CNR2MTNR1AMTNR1BTSHRRECQL | |
| Iodide SCHEMBL9307497 | 0.87 | SMN1; SMN2 (0.48) | CNR2MTNR1AMTNR1BPTPN1 | |
| Iodide SCHEMBL9308456 | 0.87 | S1PR2 (0.43) | CNR2MTNR1AMTNR1BTSHRRECQL | |
| Iodide SCHEMBL9307308 | 0.87 | SMN1; SMN2 (0.48) | CNR2MTNR1AMTNR1BPTPN1 | |
| Iodide SCHEMBL9307104 | 0.86 | MTNR1A (0.40) | CNR2THRATHRBMTNR1ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328921-A | Antagonist of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1994-07-12 | — | — | US | disclosed |