Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 1/20 | 0.65 |
| ▸ | THRB | P10828 | 1/20 | 0.65 |
| ▸ | SMPD1 | P17405 | 5/20 | 0.64 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.60 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9578512 | 1.00 | THRA (0.65) | THRATHRBSMPD1PLA2G4BPRSS1 | |
| SCHEMBL9308281 | 0.94 | SMPD1 (0.71) | THRATHRBSMPD1PLA2G4BPRSS1 | |
| SCHEMBL11239964 | 0.94 | THRA (0.57) | THRATHRBSMPD1PLA2G4BPRSS1 | |
| SCHEMBL9307466 | 0.93 | SMPD1 (0.60) | THRATHRBSMPD1PLA2G4BTSHR | |
| SCHEMBL9307706 | 0.93 | SMPD1 (0.60) | THRATHRBSMPD1PLA2G4BTSHR | |
| SCHEMBL7020183 | 0.93 | SMPD1 (0.60) | THRATHRBSMPD1PLA2G4BTSHR | |
| SCHEMBL7332411 | 0.88 | SMPD1 (0.63) | THRATHRBSMPD1PLA2G4BPRSS1 | |
| SCHEMBL2312195 | 0.88 | PLA2G4B (0.74) | THRATHRBSMPD1PLA2G4BTSHR | |
| SCHEMBL18682279 | 0.88 | PLA2G4B (0.74) | THRATHRBSMPD1PLA2G4BTSHR | |
| SCHEMBL9307551 | 0.88 | PLA2G4B (0.74) | THRATHRBSMPD1PLA2G4BTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328921-A | Antagonist of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1994-07-12 | — | — | US | disclosed |
| US-5208247-A | Antianaphylactic agents or septic shock | AMERICAN CYANAMID COMPANY (US) | 1993-05-04 | — | — | US | disclosed |
| EP-0530444-A1 | Aryl, amide, imide, and carbamate pyridine antagonists of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1993-03-10 | — | — | EP | disclosed |