Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.60 |
| ▸ | RAB9A | P51151 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.60 |
| ▸ | TP53 | P04637 | 2/20 | 0.60 |
| ▸ | CASP1 | P29466 | 2/20 | 0.60 |
| ▸ | CASP7 | P55210 | 2/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | DHODH | Q02127 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | ALPG | P10696 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9307792 | 0.91 | RAB9A (0.50) | SMN1; SMN2NPC1RAB9AKDM4EHSD17B10 | |
| SCHEMBL9307464 | 0.85 | ALPG (0.46) | SMN1; SMN2NPC1RAB9AKDM4EHSD17B10 | |
| SCHEMBL9307409 | 0.85 | HSD17B10 (0.60) | SMN1; SMN2NPC1RAB9AKDM4EHSD17B10 | |
| SCHEMBL9306095 | 0.83 | ALPG (0.60) | SMN1; SMN2NPC1RAB9AKDM4EHSD17B10 | |
| SCHEMBL9306916 | 0.83 | NTRK1 (0.51) | SMN1; SMN2NPC1RAB9AKDM4EHSD17B10 | |
| SCHEMBL9305847 | 0.81 | HSD17B10 (0.43) | SMN1; SMN2NPC1RAB9AKDM4EHSD17B10 | |
| SCHEMBL9306694 | 0.80 | SMN1; SMN2 (0.53) | SMN1; SMN2NPC1RAB9AKDM4EHSD17B10 | |
| SCHEMBL9309039 | 0.78 | AKR1B1 (0.51) | SMN1; SMN2NPC1RAB9AKDM4EHSD17B10 | |
| SCHEMBL9306771 | 0.76 | NTRK1 (0.59) | SMN1; SMN2NPC1RAB9ATP53MAPT | |
| SCHEMBL9306585 | 0.75 | KDM4E (0.44) | SMN1; SMN2NPC1RAB9AKDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5340808-A | Fused pyridazinoquinazolone derivatives as neurotrophic agents | WARNER LAMBERT COMPANY (US) | 1994-08-23 | — | — | US | disclosed |
| WO-1994011373-A1 | PYRIDAZINOQUINAZOLONE DERIVATIVES AS NEUROTROPHIC AGENTS | WARNER-LAMBERT COMPANY (US) | 1994-05-26 | — | — | WO | disclosed |