Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 1/20 | 0.59 |
| ▸ | NGFR | P08138 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 6/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.46 |
| ▸ | PLAU | P00749 | 1/20 | 0.46 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.43 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.43 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9306949 | 0.91 | P4HTM (0.51) | NTRK1NGFRRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL9306208 | 0.90 | NTRK1 (0.48) | NTRK1NGFRRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL9306916 | 0.90 | NTRK1 (0.51) | NTRK1NGFRRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL9305603 | 0.87 | MAPT (0.51) | NTRK1NGFRRAB9ANPC1TP53 | |
| SCHEMBL9309118 | 0.81 | NTRK1 (0.39) | NTRK1NGFRRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL9307464 | 0.80 | ALPG (0.46) | RAB9ANPC1SMN1; SMN2TP53KMT2A | |
| SCHEMBL9305414 | 0.79 | ELANE (0.45) | NTRK1NGFRRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL9309110 | 0.79 | SCD (0.40) | NTRK1NGFRRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL9305847 | 0.78 | HSD17B10 (0.43) | RAB9ANPC1SMN1; SMN2TP53KMT2A | |
| SCHEMBL9306694 | 0.78 | SMN1; SMN2 (0.53) | RAB9ANPC1SMN1; SMN2TP53KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5340808-A | Fused pyridazinoquinazolone derivatives as neurotrophic agents | WARNER LAMBERT COMPANY (US) | 1994-08-23 | — | — | US | claimed |
| WO-1994011373-A1 | PYRIDAZINOQUINAZOLONE DERIVATIVES AS NEUROTROPHIC AGENTS | WARNER-LAMBERT COMPANY (US) | 1994-05-26 | — | — | WO | claimed |