Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9305809 | 1.00 | THRA (0.44) | THRATHRBNPSR1HSD17B10 | |
| Iodide SCHEMBL9308855 | 0.94 | HSD17B10 (0.44) | THRATHRBNPSR1HSD17B10 | |
| Iodide SCHEMBL9306978 | 0.94 | HSD17B10 (0.44) | THRATHRBNPSR1HSD17B10 | |
| Iodide SCHEMBL9306366 | 0.91 | THRA (0.45) | THRATHRBNPSR1 | |
| Iodide SCHEMBL9309300 | 0.91 | THRA (0.45) | THRATHRBNPSR1 | |
| Iodide SCHEMBL9306246 | 0.90 | NPSR1 (0.41) | THRATHRBNPSR1HSD17B10 | |
| Iodide SCHEMBL9307697 | 0.90 | NPSR1 (0.41) | THRATHRBNPSR1HSD17B10 | |
| Iodide SCHEMBL9305749 | 0.86 | S1PR2 (0.48) | NPSR1HSD17B10 | |
| Iodide SCHEMBL9308081 | 0.86 | HSD17B10 (0.57) | NPSR1HSD17B10 | |
| Iodide SCHEMBL9307396 | 0.86 | S1PR2 (0.48) | NPSR1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328921-A | Antagonist of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1994-07-12 | — | — | US | disclosed |