Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.67 |
| ▸ | MAPT | P10636 | 3/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.67 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.67 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.67 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.67 |
| ▸ | HTR2B | P41595 | 1/20 | 0.67 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | CNR2 | P34972 | 4/20 | 0.49 |
| ▸ | CNR1 | P21554 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10390510 | 0.84 | LMNA (0.48) | LMNAMAPTCYP3A4MEN1NR1I2 | |
| SCHEMBL30317604 | 0.84 | LMNA (0.50) | LMNAMAPTCYP3A4MEN1NR1I2 | |
| SCHEMBL10381438 | 0.83 | HCRTR1 (0.61) | LMNAMAPTNPSR1TSHRMAPK1 | |
| SCHEMBL15154872 | 0.83 | LMNA (0.77) | LMNAMAPTCYP3A4MEN1NR1I2 | |
| SCHEMBL9402861 | 0.82 | LMNA (0.62) | LMNAMAPTCYP3A4MEN1NR1I2 | |
| SCHEMBL168816 | 0.81 | KMT2A (0.74) | LMNAMAPTCYP3A4MEN1NR1I2 | |
| SCHEMBL3665313 | 0.81 | KMT2A (0.74) | LMNAMAPTCYP3A4MEN1NR1I2 | |
| SCHEMBL18141371 | 0.81 | KMT2A (0.74) | LMNAMAPTCYP3A4MEN1NR1I2 | |
| SCHEMBL3962812 | 0.81 | LMNA (0.74) | LMNAMAPTCYP3A4MEN1NR1I2 | |
| SCHEMBL11738774 | 0.81 | LMNA (0.74) | LMNAMAPTCYP3A4MEN1NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328921-A | Antagonist of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1994-07-12 | — | — | US | disclosed |
| US-5208247-A | Antianaphylactic agents or septic shock | AMERICAN CYANAMID COMPANY (US) | 1993-05-04 | — | — | US | disclosed |
| EP-0530444-A1 | Aryl, amide, imide, and carbamate pyridine antagonists of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1993-03-10 | — | — | EP | disclosed |