Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9158313 | 0.88 | — | — | |
| SCHEMBL9150777 | 0.87 | SMN1; SMN2 (0.45) | PKMNPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL9154452 | 0.86 | RECQL (0.46) | PKMNPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL9140427 | 0.84 | NPC1 (0.45) | PKMNPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL9155117 | 0.84 | NPC1 (0.42) | NPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL9142828 | 0.82 | NPC1 (0.47) | PKMNPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL8197661 | 0.79 | PKM (0.49) | PKMNPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL6940744 | 0.79 | NPC1 (0.42) | NPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL8401411 | 0.77 | PKM (0.46) | PKM | |
| SCHEMBL9278296 | 0.74 | POLB (0.52) | NPC1RAB9ASMN1; SMN2HTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5278186-A | Substituted with secondary amide | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-01-11 | — | — | US | disclosed |