Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9306288 | 0.91 | MEN1 (0.38) | MEN1NR1I2LMNACHRM2CYP3A4 | |
| Iodide SCHEMBL9307788 | 0.84 | LMNA (0.45) | MEN1NR1I2LMNACHRM2CYP3A4 | |
| Iodide SCHEMBL9308201 | 0.84 | MEN1 (0.36) | MEN1NR1I2LMNACHRM2CYP3A4 | |
| Iodide SCHEMBL9306544 | 0.82 | TP53 (0.41) | LMNA | |
| Iodide SCHEMBL9306871 | 0.79 | LMNA (0.46) | MEN1LMNAMAPTKMT2A | |
| Iodide SCHEMBL9308218 | 0.79 | THRA (0.44) | — | |
| Iodide SCHEMBL9306440 | 0.79 | LMNA (0.46) | MEN1LMNAMAPTKMT2A | |
| Iodide SCHEMBL9307200 | 0.78 | THRA (0.46) | — | |
| Iodide SCHEMBL9306999 | 0.76 | POLB (0.39) | MEN1LMNAMAPTKMT2A | |
| Iodide SCHEMBL9307641 | 0.74 | TP53 (0.41) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328921-A | Antagonist of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1994-07-12 | — | — | US | disclosed |