SCHEMBL930769

SCHEMBL930769

CNNc1cccc(Br)n1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRM5 P41594 2/20 0.41
KDR P35968 2/20 0.40
CLK2 P49760 2/20 0.39
CLK1 P49759 1/20 0.39
CHRNB2 P17787 2/20 0.38
CHRNA4 P43681 2/20 0.38
NTRK1 P04629 1/20 0.35
ALDH1A1 P00352 5/20 0.35
HTR7 P34969 2/20 0.34
HTR1A P08908 1/20 0.34
DRD2 P14416 1/20 0.34
HTR2A P28223 1/20 0.34
CHRNB4 P30926 1/20 0.34
CHRNA3 P32297 1/20 0.34
MAP4K4 O95819 1/20 0.33
ROS1 P08922 1/20 0.33
PIM1 P11309 1/20 0.33
PHKG2 P15735 1/20 0.33
CDK2 P24941 1/20 0.33
FLT3 P36888 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24426603 0.88 KDR (0.43) GRM5KDRCLK2CLK1CHRNB2
SCHEMBL68226 0.84
SCHEMBL18381090 0.80 KDR (0.39) GRM5KDRCLK2CLK1CHRNB2
SCHEMBL8262887 0.78 GRM5 (0.39) GRM5KDRCLK2CLK1CHRNB2
SCHEMBL31143287 0.78 KDR (0.51) GRM5KDRCLK2CLK1CHRNB2
SCHEMBL14127502 0.78 KDR (0.51) GRM5KDRCLK2CLK1CHRNB2
SCHEMBL19151683 0.77 RAB9A (0.53) GRM5ALDH1A1KDM4EMEN1MAPT
SCHEMBL24129488 0.77 GRM5 (0.44) GRM5KDRALDH1A1
SCHEMBL24189390 0.76 ALDH1A1 (0.59) ALDH1A1MEN1MAPTKMT2AGAA
SCHEMBL5769673 0.76 GRM5 (0.40) GRM5KDRCLK2CLK1CHRNB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012088124-A2 TETRAHYDRO-AZACARBOLINE MCH-1 ANTAGONISTS, METHODS OF MAKING, AND USES THEREOF ALBANY MOLECULAR RESEARCH, INC. (US) 2012-06-28 WO disclosed
WO-2011003021-A1 AZINONE-SUBSTITUTED AZABICYCLOALKANE-INDOLE AND AZABICYCLOALKANE-PYRROLO-PYRIDINE MCH-1 ANTAGONISTS, METHODS OF MAKING, AND USE THEREOF ALBANY MOLECULAR RESEARCH, INC. (US) 2011-01-06 WO disclosed
WO-2011003012-A1 AZINONE-SUBSTITUTED AZAPOLYCYCLE MCH-1 ANTAGONISTS, METHODS OF MAKING, AND USE THEREOF ALBANY MOLECULAR RESEARCH, INC. (US) 2011-01-06 WO disclosed
WO-2011003007-A1 AZABICYCLOALKANE-INDOLE AND AZABICYCLOALKANE-PYRROLO-PYRIDINE MCH-1 ANTAGONISTS, METHODS OF MAKING, AND USE THEREOF ALBANY MOLECULAR RESEARCH, INC. (US) 2011-01-06 WO disclosed