Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.39 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9308844 | 0.94 | PPARG (0.45) | PPARGESR2AGTR1AGTR2 | |
| SCHEMBL9309571 | 0.91 | ESR2 (0.45) | PPARGESR2AGTR1AGTR2 | |
| SCHEMBL9311025 | 0.89 | PPARG (0.49) | PPARGESR2AGTR1AGTR2 | |
| SCHEMBL8312740 | 0.88 | PPARG (0.48) | PPARGESR2AGTR1AGTR2 | |
| SCHEMBL9309735 | 0.88 | PPARG (0.48) | PPARGESR2AGTR1AGTR2 | |
| SCHEMBL1894428 | 0.88 | PPARG (0.50) | PPARGAGTR1 | |
| SCHEMBL7308446 | 0.86 | PPARG (0.47) | PPARGESR2AGTR1AGTR2 | |
| SCHEMBL7312142 | 0.85 | PPARG (0.46) | PPARGESR2AGTR1AGTR2 | |
| SCHEMBL9308255 | 0.85 | PPARG (0.46) | PPARGESR2AGTR1AGTR2 | |
| SCHEMBL9308863 | 0.84 | PPARG (0.46) | PPARGESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5358950-A | Useful in treatment of cardiovascular diseases | LABORATOIRES UPSA (FR) | 1994-10-25 | — | — | US | disclosed |
| US-5217973-A | Treatment of cardiovascular diseases such as hypertension, cardiac insufficiency and diseases of the arterial walls | LABORATOIRES UPSA (FR) | 1993-06-08 | — | — | US | disclosed |
| EP-0424317-A2 | Pyrimidines | CIBA-GEIGY AG (CH) | 1991-04-24 | — | — | EP | disclosed |