Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.37 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.37 |
| ▸ | APLNR | P35414 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
| ▸ | MYC | P01106 | 1/20 | 0.35 |
| ▸ | WDR5 | P61964 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9311025 | 0.85 | PPARG (0.49) | PPARGESR2AGTR1AGTR2APLNR | |
| SCHEMBL9307715 | 0.85 | PPARG (0.49) | PPARGESR2AGTR1AGTR2 | |
| SCHEMBL8312740 | 0.85 | PPARG (0.48) | PPARGESR2AGTR1AGTR2 | |
| SCHEMBL9309735 | 0.85 | PPARG (0.48) | PPARGESR2AGTR1AGTR2APLNR | |
| SCHEMBL7308446 | 0.83 | PPARG (0.47) | PPARGESR2AGTR1AGTR2APLNR | |
| SCHEMBL9308255 | 0.81 | PPARG (0.46) | PPARGESR2AGTR1AGTR2APLNR | |
| SCHEMBL9308863 | 0.81 | PPARG (0.46) | PPARGESR2ACHEFFAR1AKR1B1 | |
| SCHEMBL9308512 | 0.81 | PPARG (0.45) | PPARGESR2AGTR1AGTR2ACHE | |
| SCHEMBL9308565 | 0.81 | PPARG (0.45) | PPARGAGTR1 | |
| SCHEMBL9846024 | 0.81 | PPARG (0.47) | PPARGESR2AGTR1AGTR2APLNR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0628046-B1 | TRIAZOLOPYRIMIDIN DERIVATIVES AS ANTIOTENSIN II RECEPTOR ANTAGONISTS | UNION PHARMA SCIENT APPL (FR) | 1999-05-12 | — | — | EP | disclosed |
| US-5387747-A | Used in the treatment and prevention of cardiovascular diseases: hypertension, cardiac insufficiency and atherosclerosis | LABORATOIRES UPSA (FR) | 1995-02-07 | — | — | US | disclosed |
| EP-0628046-A1 | TRIAZOLOPYRIMIDIN DERIVATIVES AS ANTIOTENSIN II RECEPTOR ANTAGONISTS | LABORATOIRES UPSA (FR) | 1994-12-14 | — | — | EP | disclosed |
| WO-1993017024-A1 | TRIAZOLOPYRIMIDIN DERIVATIVES AS ANTIOTENSIN II RECEPTOR ANTAGONISTS | LABORATOIRES UPSA (FR) | 1993-09-02 | — | — | WO | disclosed |
| US-5231094-A | Cardiovascular disorders | SOCIETE ANONYME: LABORATOIRES UPSA (FR) | 1993-07-27 | — | — | US | disclosed |