Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9153940 | 0.85 | MAOB (0.43) | TP53MAPTTDP1NPC1RAB9A | |
| SCHEMBL9155117 | 0.84 | NPC1 (0.42) | NPC1RAB9A | |
| SCHEMBL9307958 | 0.79 | TP53 (0.39) | TP53MAPTTDP1NPC1RAB9A | |
| SCHEMBL9150777 | 0.76 | SMN1; SMN2 (0.45) | MAPTNPC1RAB9AKMT2AMEN1 | |
| SCHEMBL6940744 | 0.74 | NPC1 (0.42) | NPC1RAB9A | |
| SCHEMBL9158313 | 0.73 | — | — | |
| SCHEMBL9307944 | 0.73 | NPC1 (0.38) | TP53TDP1NPC1RAB9AKMT2A | |
| SCHEMBL8785534 | 0.73 | TP53 (0.40) | TP53MAPTKDM4EHSD17B10LMNA | |
| SCHEMBL8786216 | 0.72 | SMN1; SMN2 (0.45) | TP53MAPTTDP1NPC1RAB9A | |
| SCHEMBL9154464 | 0.72 | KDR (0.48) | TP53MAPTRAB9AKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5278186-A | Substituted with secondary amide | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-01-11 | — | — | US | disclosed |
| EP-0514546-A1 | CHROMENE DERIVATIVES, THEIR PRODUCTION AND USE. | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1992-11-25 | — | — | EP | disclosed |
| WO-1991012249-A1 | CHROMENE DERIVATIVES, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1991-08-22 | — | — | WO | disclosed |