Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | CASP6 | P55212 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | HTT | P42858 | 5/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | CASP1 | P29466 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5393255 | 0.83 | POLB (0.46) | NPC1POLBRAB9APDGFRBPDGFRA | |
| SCHEMBL2936414 | 0.79 | TDP1 (0.42) | NPC1RAB9AALDH1A1MAPTMEN1 | |
| SCHEMBL20062355 | 0.78 | ALDH1A1 (0.54) | NPC1POLBRAB9APDGFRBPDGFRA | |
| SCHEMBL29350099 | 0.76 | NPC1 (0.65) | NPC1POLBRAB9APDGFRBPDGFRA | |
| SCHEMBL150476 | 0.76 | NPC1 (0.65) | NPC1POLBRAB9APDGFRBPDGFRA | |
| SCHEMBL6647315 | 0.74 | NPC1 (0.62) | NPC1POLBRAB9APDGFRBPDGFRA | |
| SCHEMBL30083328 | 0.74 | ALOX15 (0.60) | POLBRAB9AALDH1A1HTTTP53 | |
| SCHEMBL103 | 0.74 | ALOX15 (0.60) | POLBRAB9AALDH1A1HTTTP53 | |
| SCHEMBL21187608 | 0.73 | ALDH1A1 (0.57) | NPC1POLBRAB9APDGFRBPDGFRA | |
| SCHEMBL13495403 | 0.73 | PDGFRB (0.50) | NPC1POLBRAB9APDGFRBPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4622967-A1 | COMPOUNDS THAT INHIBIT PKMYT1 | Exelixis, Inc. (US) | 2025-10-01 | — | — | EP | disclosed |
| WO-2024112853-A1 | COMPOUNDS THAT INHIBIT PKMYT1 | EXELIXIS, INC. (US) | 2024-05-30 | — | — | WO | disclosed |
| WO-2024112853-A1 | COMPOUNDS THAT INHIBIT PKMYT1 | EXELIXIS, INC. (US) | 2024-05-30 | — | — | WO | disclosed |
| US-5283335-A | Controlling (mono or di)cotyledenous plants | AMERICAN CYANAMID COMPANY (US) | 1994-02-01 | — | — | US | disclosed |