Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.43 |
| ▸ | RAD52 | P43351 | 2/20 | 0.43 |
| ▸ | APAF1 | O14727 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | BLM | P54132 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | XBP1 | P17861 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | THRA | P10827 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | PTPRB | P23467 | 1/20 | 0.39 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.39 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9306166 | 1.00 | LMNA (0.43) | LMNAHSP90AA1RAD52APAF1ALDH1A1 | |
| Iodide SCHEMBL9308394 | 1.00 | LMNA (0.43) | LMNAHSP90AA1RAD52APAF1ALDH1A1 | |
| Iodide SCHEMBL9305596 | 0.91 | THRA (0.43) | SMN1; SMN2HTTTHRATHRBATM | |
| Iodide SCHEMBL9308032 | 0.91 | THRA (0.43) | SMN1; SMN2HTTTHRATHRBATM | |
| Iodide SCHEMBL9305571 | 0.90 | LMNA (0.43) | LMNAHSP90AA1RAD52APAF1ALDH1A1 | |
| Iodide SCHEMBL9307977 | 0.90 | LMNA (0.43) | LMNAHSP90AA1RAD52APAF1ALDH1A1 | |
| Iodide SCHEMBL9307037 | 0.90 | LMNA (0.43) | LMNAHSP90AA1RAD52APAF1ALDH1A1 | |
| Iodide SCHEMBL9308204 | 0.90 | THRA (0.42) | THRATHRBATMSTAT3PTPRB | |
| Iodide SCHEMBL9308285 | 0.90 | THRA (0.42) | THRATHRBATMSTAT3PTPRB | |
| Iodide SCHEMBL9305560 | 0.88 | THRA (0.42) | LMNAHSP90AA1RAD52APAF1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328921-A | Antagonist of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1994-07-12 | — | — | US | disclosed |