Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 3/20 | 0.51 |
| ▸ | CNR2 | P34972 | 3/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9307112 | 1.00 | CNR1 (0.51) | CNR1CNR2NPSR1EPHX2KCNH2 | |
| Iodide SCHEMBL9306841 | 0.91 | CNR1 (0.50) | CNR1CNR2NPSR1EPHX2KCNH2 | |
| Iodide SCHEMBL9306405 | 0.91 | CNR1 (0.50) | CNR1CNR2NPSR1EPHX2KCNH2 | |
| Iodide SCHEMBL9305722 | 0.91 | CNR1 (0.50) | CNR1CNR2NPSR1EPHX2KCNH2 | |
| Iodide SCHEMBL9305950 | 0.91 | CNR1 (0.50) | CNR1CNR2NPSR1EPHX2KCNH2 | |
| Iodide SCHEMBL9307388 | 0.87 | THRB (0.43) | CNR1CNR2NPSR1 | |
| Iodide SCHEMBL9307810 | 0.87 | THRB (0.43) | CNR1CNR2NPSR1 | |
| Iodide SCHEMBL9307180 | 0.85 | THRA (0.52) | CNR2 | |
| Iodide SCHEMBL9306505 | 0.85 | THRA (0.52) | CNR2 | |
| Iodide SCHEMBL9305452 | 0.84 | CNR1 (0.47) | CNR1CNR2NPSR1EPHX2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328921-A | Antagonist of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1994-07-12 | — | — | US | disclosed |