Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PROKR1 | Q8TCW9 | 15/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.39 |
| ▸ | HTR3B | O95264 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.39 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28549220 | 0.74 | PROKR1 (0.40) | PROKR1 | |
| SCHEMBL827405 | 0.73 | ALDH1A1 (0.41) | PROKR1ALDH1A1GAAMAPT | |
| SCHEMBL19672204 | 0.72 | PROKR1 (0.39) | PROKR1ALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL5743227 | 0.71 | ALDH1A1 (0.40) | PROKR1ALDH1A1GAAMAPT | |
| SCHEMBL3836493 | 0.71 | PARP1 (0.50) | GRM5GAAMAPTHTTHTR3E | |
| Hydrochloric Acid SCHEMBL22042746 | 0.71 | PRSS1 (0.40) | PROKR1 | |
| SCHEMBL1727183 | 0.70 | PROKR1 (0.38) | PROKR1 | |
| SCHEMBL28819044 | 0.69 | PROKR1 (0.47) | PROKR1GAAMAPT | |
| SCHEMBL11099112 | 0.67 | PROKR1 (0.46) | PROKR1 | |
| SCHEMBL11340185 | 0.67 | KDM4E (0.55) | PROKR1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011002407-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |