Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | APAF1 | O14727 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.39 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | THRA | P10827 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9306128 | 1.00 | LMNA (0.40) | LMNAMAPTKDM4EAPAF1ALDH1A1 | |
| Iodide SCHEMBL9308427 | 0.93 | LMNA (0.42) | LMNAMAPTKDM4EAPAF1ALDH1A1 | |
| Iodide SCHEMBL9308303 | 0.92 | ATM (0.40) | ATMRAF1MAP2K1NR1H4LPAR1 | |
| Iodide SCHEMBL9307756 | 0.91 | RAF1 (0.49) | LMNAMAPTKDM4EAPAF1ALDH1A1 | |
| Iodide SCHEMBL9307091 | 0.90 | LMNA (0.45) | LMNAMAPTKDM4EAPAF1ALDH1A1 | |
| Iodide SCHEMBL9307898 | 0.89 | THRA (0.40) | LMNAMAPTKDM4EAPAF1ALDH1A1 | |
| Iodide SCHEMBL9305446 | 0.88 | ATM (0.40) | LMNAMAPTATMHTTSMN1; SMN2 | |
| Iodide SCHEMBL9307400 | 0.87 | MAPT (0.45) | LMNAMAPTATMRAF1MAP2K1 | |
| Iodide SCHEMBL9306943 | 0.87 | LMNA (0.43) | LMNAMAPTRAF1MAP2K1LPAR1 | |
| Iodide SCHEMBL9307428 | 0.86 | MAPT (0.41) | LMNAMAPTATMNR1H4LPAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328921-A | Antagonist of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1994-07-12 | — | — | US | disclosed |