Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | RAD52 | P43351 | 1/20 | 0.44 |
| ▸ | APAF1 | O14727 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | XBP1 | P17861 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.39 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.38 |
| ▸ | THRA | P10827 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.37 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9307654 | 1.00 | LMNA (0.44) | LMNAHSP90AA1SMN1; SMN2RAD52APAF1 | |
| Iodide SCHEMBL9307049 | 1.00 | LMNA (0.44) | LMNAHSP90AA1SMN1; SMN2RAD52APAF1 | |
| Iodide SCHEMBL9306634 | 0.94 | LMNA (0.41) | LMNAHSP90AA1SMN1; SMN2RAD52APAF1 | |
| Iodide SCHEMBL9309278 | 0.94 | LMNA (0.41) | LMNAHSP90AA1SMN1; SMN2RAD52APAF1 | |
| Iodide SCHEMBL9307369 | 0.90 | LMNA (0.41) | LMNATP53PLA2G4BTHRATHRB | |
| Iodide SCHEMBL9307732 | 0.90 | LMNA (0.41) | LMNATP53PLA2G4BTHRATHRB | |
| Iodide SCHEMBL9307773 | 0.87 | LMNA (0.47) | LMNAHSP90AA1SMN1; SMN2RAD52APAF1 | |
| Iodide SCHEMBL9307641 | 0.86 | TP53 (0.41) | LMNATP53PLA2G4BTHRATHRB | |
| Iodide SCHEMBL9306544 | 0.85 | TP53 (0.41) | LMNATP53PLA2G4BTHRATHRB | |
| Iodide SCHEMBL9307788 | 0.83 | LMNA (0.45) | LMNAHSP90AA1SMN1; SMN2RAD52APAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328921-A | Antagonist of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1994-07-12 | — | — | US | disclosed |