Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | RAD52 | P43351 | 1/20 | 0.47 |
| ▸ | APAF1 | O14727 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | XBP1 | P17861 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.45 |
| ▸ | STAT3 | P40763 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9309582 | 0.89 | LTB4R2 (0.46) | LTB4R2STAT3TP53TSHR | |
| Iodide SCHEMBL9308416 | 0.87 | LMNA (0.44) | LMNAHSP90AA1SMN1; SMN2RAD52APAF1 | |
| Iodide SCHEMBL9307654 | 0.87 | LMNA (0.44) | LMNAHSP90AA1SMN1; SMN2RAD52APAF1 | |
| Iodide SCHEMBL9307049 | 0.87 | LMNA (0.44) | LMNAHSP90AA1SMN1; SMN2RAD52APAF1 | |
| Iodide SCHEMBL9306166 | 0.86 | LMNA (0.43) | LMNAHSP90AA1SMN1; SMN2RAD52APAF1 | |
| Iodide SCHEMBL9308066 | 0.86 | LMNA (0.43) | LMNAHSP90AA1SMN1; SMN2RAD52APAF1 | |
| Iodide SCHEMBL9308394 | 0.86 | LMNA (0.43) | LMNAHSP90AA1SMN1; SMN2RAD52APAF1 | |
| Iodide SCHEMBL9307977 | 0.86 | LMNA (0.43) | LMNAHSP90AA1SMN1; SMN2RAD52APAF1 | |
| Iodide SCHEMBL9305571 | 0.86 | LMNA (0.43) | LMNAHSP90AA1SMN1; SMN2RAD52APAF1 | |
| Iodide SCHEMBL9307037 | 0.86 | LMNA (0.43) | LMNAHSP90AA1SMN1; SMN2RAD52APAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328921-A | Antagonist of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1994-07-12 | — | — | US | disclosed |
| US-5208247-A | Antianaphylactic agents or septic shock | AMERICAN CYANAMID COMPANY (US) | 1993-05-04 | — | — | US | disclosed |
| EP-0530444-A1 | Aryl, amide, imide, and carbamate pyridine antagonists of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1993-03-10 | — | — | EP | disclosed |