Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5809049 | 0.90 | ALDH1A1 (0.47) | ALDH1A1HTTHPGDKDM4ERECQL | |
| SCHEMBL27346013 | 0.86 | GPR84 (0.37) | ALDH1A1HTTHPGDKDM4ERECQL | |
| SCHEMBL7309807 | 0.86 | ALDH1A1 (0.44) | ALDH1A1HTTHPGDKDM4ERECQL | |
| SCHEMBL9308574 | 0.85 | ALDH1A1 (0.43) | ALDH1A1HTTHPGDKDM4ERECQL | |
| SCHEMBL9206394 | 0.85 | ALDH1A1 (0.61) | ALDH1A1HTTHPGDKDM4ERECQL | |
| SCHEMBL7423269 | 0.85 | ALDH1A1 (0.43) | ALDH1A1HTTHPGDKDM4ERECQL | |
| SCHEMBL7303130 | 0.84 | ALDH1A1 (0.42) | ALDH1A1HTTHPGDKDM4ERECQL | |
| SCHEMBL3027865 | 0.83 | ALDH1A1 (0.50) | ALDH1A1HTTHPGDKDM4ERECQL | |
| SCHEMBL7268595 | 0.82 | ALDH1A1 (0.41) | ALDH1A1HTTHPGDKDM4ERECQL | |
| SCHEMBL27296914 | 0.81 | GPR84 (0.34) | ALDH1A1HTTHPGDKDM4ERECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5374646-A | Treatment or prophylasix of hypertension and diseases associated with cognitive disorders | GLAXO GROUP LIMITED (GB) | 1994-12-20 | — | — | US | disclosed |
| EP-0434249-A2 | Benzofuran derivatives | GLAXO GROUP LIMITED (GB) | 1991-06-26 | — | — | EP | disclosed |