Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.76 |
| ▸ | MEN1 | O00255 | 4/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.54 |
| ▸ | DRD2 | P14416 | 2/20 | 0.53 |
| ▸ | DRD4 | P21917 | 2/20 | 0.53 |
| ▸ | DRD3 | P35462 | 2/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.53 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.53 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.53 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10688767 | 0.87 | POLB (1.00) | POLBMEN1KMT2ADRD2DRD4 | |
| SCHEMBL29880432 | 0.87 | POLB (1.00) | POLBMEN1KMT2ADRD2DRD4 | |
| SCHEMBL9308870 | 0.84 | POLB (0.77) | POLBMEN1KMT2AHDAC6HDAC3 | |
| SCHEMBL31667178 | 0.84 | POLB (0.77) | POLBMEN1KMT2AHDAC6HDAC3 | |
| SCHEMBL9309432 | 0.84 | MEN1 (0.65) | POLBMEN1KMT2AHDAC6HDAC3 | |
| SCHEMBL14207256 | 0.83 | PTGS1 (0.66) | POLBMEN1KMT2AHDAC6HDAC1 | |
| SCHEMBL9308514 | 0.81 | POLB (0.77) | POLBMEN1KMT2AHDAC6HDAC3 | |
| SCHEMBL9309713 | 0.80 | POLB (0.62) | POLBMEN1KMT2AHDAC6HDAC3 | |
| SCHEMBL28841194 | 0.79 | HDAC1 (0.53) | HDAC6HDAC1HDAC8CHRM1 | |
| SCHEMBL4506469 | 0.78 | ALDH1A1 (0.69) | POLBMEN1KMT2ADRD4GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5371226-A | Hypotensive agents | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1994-12-06 | — | — | US | disclosed |
| EP-0561252-A1 | 2-Oxoquinoline derivatives as angiotensin II antagonists | MERCK PATENT GmbH (DE) | 1993-09-22 | — | — | EP | disclosed |