Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | CA12 | O43570 | 2/20 | 0.56 |
| ▸ | CA1 | P00915 | 2/20 | 0.56 |
| ▸ | CA4 | P22748 | 2/20 | 0.56 |
| ▸ | CA7 | P43166 | 2/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.50 |
| ▸ | DHODH | Q02127 | 1/20 | 0.50 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.49 |
| ▸ | PLK1 | P53350 | 3/20 | 0.49 |
| ▸ | PLK3 | Q9H4B4 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9309713 | 0.84 | POLB (0.62) | MEN1KMT2APOLBHDAC6HDAC3 | |
| SCHEMBL9308859 | 0.84 | POLB (0.76) | MEN1KMT2APOLBHDAC6HDAC3 | |
| SCHEMBL31667178 | 0.77 | POLB (0.77) | MEN1KMT2APOLBHDAC6HDAC3 | |
| SCHEMBL9308870 | 0.77 | POLB (0.77) | MEN1KMT2APOLBHDAC6HDAC3 | |
| SCHEMBL29880432 | 0.77 | POLB (1.00) | MEN1KMT2APOLB | |
| SCHEMBL10688767 | 0.77 | POLB (1.00) | MEN1KMT2APOLB | |
| SCHEMBL17425270 | 0.75 | HDAC6 (0.76) | POLBHDAC6HDAC3HDAC1HDAC8 | |
| SCHEMBL28166449 | 0.74 | TNF (0.60) | MEN1KMT2AHDAC6HDAC3HDAC1 | |
| SCHEMBL2028671 | 0.74 | DHODH (0.86) | MEN1KMT2ACA12CA1CA4 | |
| SCHEMBL9307390 | 0.74 | POLB (0.47) | MEN1KMT2APOLBHDAC6HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5371226-A | Hypotensive agents | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1994-12-06 | — | — | US | disclosed |
| EP-0561252-A1 | 2-Oxoquinoline derivatives as angiotensin II antagonists | MERCK PATENT GmbH (DE) | 1993-09-22 | — | — | EP | disclosed |