Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.48 |
| ▸ | DPP4 | P27487 | 2/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.42 |
| ▸ | DHFR | P00374 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.40 |
| ▸ | C1S | P09871 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PHGDH | O43175 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5088940 | 0.84 | KCNH2 (0.43) | RAB9AKCNH2DPP4ADRB1DHFR | |
| SCHEMBL992823 | 0.83 | DPP4 (0.51) | RAB9ANPC1KCNH2DPP4ADRB1 | |
| SCHEMBL14191682 | 0.83 | HTR2A (0.41) | KCNH2MAPTALDH1A1KDM4E | |
| SCHEMBL9310603 | 0.82 | KCNH2 (0.47) | RAB9AKCNH2DPP4ADRB1DHFR | |
| SCHEMBL9310505 | 0.81 | DPP4 (0.43) | RAB9ANPC1KCNH2DPP4ADRB1 | |
| SCHEMBL9310579 | 0.80 | NPC1 (0.45) | RAB9ANPC1RECQLMAPTALDH1A1 | |
| SCHEMBL9312087 | 0.78 | KCNH2 (0.46) | RAB9ANPC1KCNH2DPP4ADRB1 | |
| SCHEMBL9311527 | 0.78 | NPC1 (0.45) | RAB9ANPC1RECQLDPP4MAPT | |
| SCHEMBL9312009 | 0.78 | MAPT (0.49) | RAB9AKCNH2DPP4ADRB1MAPT | |
| SCHEMBL14191683 | 0.77 | FBP1 (0.39) | KCNH2DPP4MAPTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5292738-A | Anti-virally active pyridazinamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-03-08 | — | — | US | disclosed |
| US-5157035-A | Viricides | JANSSEN PHARMACEUTICA N. V. (BE) | 1992-10-20 | — | — | US | disclosed |
| US-5001125-A | Anti-virally active pyridazinamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-03-19 | — | — | US | disclosed |
| EP-0156433-B1 | ANTI-VIRALLY ACTIVE PYRIDAZINAMINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-02-27 | — | — | EP | disclosed |
| EP-0156433-A2 | Anti-virally active pyridazinamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-10-02 | — | — | EP | disclosed |