Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | HTT | P42858 | 3/20 | 0.59 |
| ▸ | USP2 | O75604 | 2/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | UBE2M | P61081 | 1/20 | 0.53 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.53 |
| ▸ | MLNR | O43193 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | PHGDH | O43175 | 3/20 | 0.51 |
| ▸ | TEAD1 | P28347 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9311270 | 0.92 | LMNA (0.66) | LMNAHTTUSP2MAPK1KDM4E | |
| SCHEMBL21856300 | 0.87 | EPHX2 (0.53) | HTTMAPK1MAPTEPHX2KMT2A | |
| SCHEMBL30027494 | 0.87 | EPHX2 (0.53) | HTTMAPK1MAPTEPHX2KMT2A | |
| SCHEMBL21958729 | 0.87 | EPHX2 (0.53) | HTTMAPK1MAPTEPHX2KMT2A | |
| SCHEMBL21958743 | 0.87 | EPHX2 (0.70) | EPHX2KMT2AMEN1UBE2MDCUN1D1 | |
| SCHEMBL9309796 | 0.85 | KDM4E (0.65) | LMNAHTTUSP2KDM4EMAPT | |
| SCHEMBL21856361 | 0.84 | EPHX2 (0.57) | LMNAHTTEPHX2KMT2AMEN1 | |
| SCHEMBL21856356 | 0.84 | EPHX2 (0.57) | LMNAHTTEPHX2KMT2AMEN1 | |
| SCHEMBL4597303 | 0.83 | LMNA (0.54) | LMNAHTTUSP2MAPK1KDM4E | |
| SCHEMBL21958169 | 0.82 | MLNR (0.56) | EPHX2KMT2AMEN1UBE2MDCUN1D1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5292738-A | Anti-virally active pyridazinamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-03-08 | — | — | US | disclosed |
| US-5157035-A | Viricides | JANSSEN PHARMACEUTICA N. V. (BE) | 1992-10-20 | — | — | US | disclosed |
| US-5001125-A | Anti-virally active pyridazinamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-03-19 | — | — | US | disclosed |
| EP-0156433-B1 | ANTI-VIRALLY ACTIVE PYRIDAZINAMINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-02-27 | — | — | EP | disclosed |
| EP-0156433-A2 | Anti-virally active pyridazinamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-10-02 | — | — | EP | disclosed |